TIM23 Complex: Facilitating Molecule Import Into Mitochondrial Inner Membrane

Target Name: Mitochondrial import inner membrane translocase 23 (TIM23) complex

NCBI ID: P16448

Mitochondrial import inner membrane translocase 23 (TIM23) complex

Other Name(s): TIM23 complex

TIM23 Complex: Facilitating Molecule Import Into Mitochondrial Inner Membrane

Mitochondrial import inner membrane translocase 23 (TIM23) complex is a protein that plays a crucial role in the function of mitochondria, which are organelles responsible for generating energy in the form of ATP in cells throughout the body. TIM23 complex is a protein complex that is composed of multiple subunits that work together to facilitate the import of molecules into the mitochondrial inner membrane.

The mitochondria are responsible for generating the majority of the ATP that is produced in the body, and they do this by using a process called mitochondrial import. During this process, molecules such as proteins, lipids, and carbohydrates are transported into the mitochondria and are processed and broken down to produce ATP.

TIM23 complex is a protein complex that is essential for the proper functioning of the mitochondria. It is composed of multiple subunits, including a protein called TIM23, which is the main subunit of the complex. Other subunits of the complex include proteins such as TIM24, TIM25, and TIP612, which work together to facilitate the import of molecules into the mitochondrial inner membrane.

TIM23 is a transmembrane protein that is located on the inner side of the mitochondrial membrane. It has a molecular weight of approximately 42 kDa and is composed of multiple domains, including an N-terminus, a transmembrane region, and an C-terminus. The N-terminus of TIM23 is located on the cytoplasm side of the membrane, while the C-terminus is located on the mitochondrial inner membrane.

The transmembrane region of TIM23 is responsible for the protein's ability to span the mitochondrial membrane and interact with other proteins on the inner side of the membrane. This region is characterized by multiple positively charged residues, including a single negatively charged alanine residue at position 192.

The C-terminus of TIM23 is responsible for the protein's ability to interact with the cytoplasm and the mitochondrial inner membrane. This region is characterized by multiple negatively charged residues, including a single negatively charged aspartate residue at position 216.

TIM23 complex functions as a protein-protein interaction (PPI) domain and plays a crucial role in regulating the import of molecules into the mitochondrial inner membrane. It does this by interacting with multiple proteins on the inner side of the membrane, including components of the mitochondrial inner membrane transport system.

One of the ways that TIM23 complex functions is by interacting with the protein known as ATP-binding Cassette (ABC) subfamily protein 2 (ABC2). This protein is responsible for regulating the import of molecules into the mitochondria and is composed of multiple domains, including an N-terminus, a transmembrane region, and an C-terminus.

TIM23 complex interacts with ABC2 by using its transmembrane region to form a complex with the protein. This interaction between TIM23 and ABC2 allows the two proteins to work together to regulate the import of molecules into the mitochondria.

Another way that TIM23 complex functions is by interacting with the protein known as Mitofusin. Mitofusin is a protein that is involved in the regulation of mitochondrial fusion and is composed of multiple domains, including an N-terminus, a transmembrane region, and an C-terminus.

TIM23 complex interacts with Mitofusin by using its transmembrane region to form a complex with the protein. This interaction between TIM23 and Mitofusin allows the two proteins to work together to regulate the import of molecules into the mitochondria.

In conclusion, Mitochondrial import inner membrane translocase 23 (TIM23) complex is a protein that plays a crucial role in the function of mitochondria. It is composed of multiple subunits that work together to facilitate

Protein Name: Mitochondrial Import Inner Membrane Translocase 23 (TIM23) Complex

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